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Diphenhydramine (/ˌdaɪfɛnˈhaɪdrəmiːn/; abbreviated DPH, sometimes DHM) is a first-generation antihistamine possessing anticholinergic, antitussive, antiemetic, and sedative properties that is mainly used to treat allergies. It is also used in the management of drug-induced parkinsonism and other extrapyramidal symptoms. The drug has a strong hypnotic effect and is FDA-approved as a nonprescription sleep aid, especially in the form of diphenhydramine citrate.

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  • Diphenhydramine (/ˌdaɪfɛnˈhaɪdrəmiːn/; abbreviated DPH, sometimes DHM) is a first-generation antihistamine possessing anticholinergic, antitussive, antiemetic, and sedative properties that is mainly used to treat allergies. It is also used in the management of drug-induced parkinsonism and other extrapyramidal symptoms. The drug has a strong hypnotic effect and is FDA-approved as a nonprescription sleep aid, especially in the form of diphenhydramine citrate.
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  • External Image
ATC prefix
  • D04
ATC suffix
  • AA32
ATC supplemental
  • ,
Bioavailability
CAS number
  • 58-73-1
ChEBI
  • 4636
DrugBank
  • DB01075
FDA UNII code
  • 8GTS82S83M
IUPAC name
  • 2-(diphenylmethoxy)-N,N-dimethylethanamine
PubChem
  • 3100
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