Douglas County (county code DG) is a county located in the U.S. state of Kansas. As of the 2010 census, the county population was 110,826, making it the fifth-most populous county in Kansas. Its county seat and most populous city is Lawrence.Douglas County comprises the Lawrence, KS Metropolitan Statistical Area, which is also included in the Kansas City-Overland Park-Kansas City, MO-KS Combined Statistical Area.