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Imatinib (INN), marketed by Novartis as Gleevec (Canada, South Africa and the USA) or Glivec (Australia, Europe and Latin America), and sometimes referred to by its investigational name STI-571, is a tyrosine-kinase inhibitor used in the treatment of multiple cancers, most notably Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML).Gleevec is actually the beta crystalline form of imatinib mesilate, the mesylate salt of imatinib.In order to survive, cells need signaling through proteins (signal cascade) to keep them alive.

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  • Imatinib (INN), marketed by Novartis as Gleevec (Canada, South Africa and the USA) or Glivec (Australia, Europe and Latin America), and sometimes referred to by its investigational name STI-571, is a tyrosine-kinase inhibitor used in the treatment of multiple cancers, most notably Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML).Gleevec is actually the beta crystalline form of imatinib mesilate, the mesylate salt of imatinib.In order to survive, cells need signaling through proteins (signal cascade) to keep them alive.
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foaf:depiction
  • External Image
ATC prefix
  • L01
ATC suffix
  • XE01
Bioavailability
CAS number
  • 152459-95-5
CAS supplemental
  • (mesilate)
ChEBI
  • 45783
DrugBank
  • DB00619
FDA UNII code
  • BKJ8M8G5HI
IUPAC name
  • 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide
PubChem
  • 5291
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