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Inoculation (also known as variolation) was a historical method for the prevention of smallpox by deliberate introduction into the skin of material from smallpox pustules. This generally produced a less severe infection than naturally-acquired smallpox, but still induced immunity to it. The term entered medical English through horticultural usage meaning to graft a bud (or eye) from one plant into another. It is derived from the Latin in + oculus (eye).

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  • Inoculation (also known as variolation) was a historical method for the prevention of smallpox by deliberate introduction into the skin of material from smallpox pustules. This generally produced a less severe infection than naturally-acquired smallpox, but still induced immunity to it. The term entered medical English through horticultural usage meaning to graft a bud (or eye) from one plant into another. It is derived from the Latin in + oculus (eye).
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