The Big River is a tributary of the Meramec River in east-central Missouri. The river rises in western Iron County (37.6899°N 90.9656°W / 37.6899; -90.9656 (Big River (source))), near the summit of Johnson Mountain and the locale of Enough; it flows through Washington County, Saint Francois County, and Jefferson County. It forms part of the boundary between Jefferson County and Saint Francois County and also part of the boundary between Jefferson County and Washington County.
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