The Crocodile Lake National Wildlife Refuge is part of the United States National Wildlife Refuge System, located in north Key Largo, less than 40 miles (60 km) south of Miami off SR 905 (Card Sound Road). The 6,686 acre (27.1 km2) refuge (located in Monroe County, Florida) opened during the year of 1980, under the Land and Water Conservation Fund Act of 1965 and the Endangered Species Act of 1973.
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