Grimes is an unincorporated community in Roger Mills County, Oklahoma, United States. Grimes is located in the southern part of the county, 11.4 miles (18.3 km) south-southwest of Cheyenne. The Grimes post office opened on March 1, 1901, and closed on November 26, 1971. The community was named for acting Oklahoma territorial governor William C. Grimes.
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