HMS Medusa was a 38-gun 5th rate frigate of the Royal Navy that served in the Napoleonic Wars. Launched on 14 April 1801, she took part in the Action of 5 October 1804 against a Spanish squadron, in the River Plate Expedition in 1807, and made several captures of enemy ships, before being converted to a hospital ship in 1813. She was broken up in 1816.
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