Isabella Macdonald, née Clark (1811 – 28 December 1857) was the first wife of John A. Macdonald, one of the fathers of the Canadian federation. The couple were related by sharing their maternal grandmother; cousin marriage was not uncommon then.During their marriage, he became the premier of the Province of Canada in 1856.She became ill after just two years of marriage, and developed an addiction to opium mixed with wine (Laudanum).
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