The highest specific impulse chemical rockets (liquid-propellant rockets) use liquid fuel propellants.Approximately 170 different liquid propellants have undergone lab testing. This estimate excludes minor changes to a specific propellant such as propellant additives, corrosion inhibitors, or stabilizers. In the U.S. alone at least 25 different propellant combinations have been flown. However, there has not been a completely new propellant used in flight for nearly 30 years.
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