M-121 is a state trunkline highway in West Michigan. The highway follows Chicago Drive, a local roadway, from Zeeland to Grandville. Chicago Drive itself runs past the M-121 segment on either side from Holland to Wyoming. The roadway passes through rural farmland on a route that runs parallel to Interstate 196 (I-196). M-121 forms the main street through the center of Hudsonville as it runs southwest–northeast.
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