Maryland Route 404 (MD 404) is a major highway on Maryland's Eastern Shore in the United States. It runs 24.61 miles (39.61 km) from MD 662 in Wye Mills on the border of Queen Anne's and Talbot counties, southeast to the Delaware state line in Caroline County, where the road continues as Delaware Route 404 (DE 404) to Nassau (near Rehoboth Beach).
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