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Methotrexate (INN, AAN, BAN and USAN; /mɛθɵˈtrɛkseɪt/), abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug.It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid.Methotrexate began to replace the more toxic antifolate aminopterin starting in the 1950s.

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  • Methotrexate (INN, AAN, BAN and USAN; /mɛθɵˈtrɛkseɪt/), abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug.It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid.Methotrexate began to replace the more toxic antifolate aminopterin starting in the 1950s.
rdfs:seeAlso
foaf:depiction
  • External Image
ATC prefix
  • L01
ATC suffix
  • BA01
Bioavailability
CAS number
  • 59-05-2
ChEBI
  • 44185
DrugBank
  • DB00563
FDA UNII code
  • YL5FZ2Y5U1
IUPAC name
  • (2S)-2-[(4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)amino]pentanedioic acid
PubChem
  • 126941
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