Missouri Wine refers to wine made from grapes grown in the U.S. state of Missouri. German immigrants in the early-to-mid-19th century, founded the wine industry in Missouri, resulting in its wine corridor being called the Missouri "Rhineland". Later Italian immigrants also entered wine production. In the mid-1880s, more wine was produced by volume in Missouri than in any other state. Before Prohibition, Missouri was the second-largest wine-producing state in the nation.