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A monolithic HPLC column, or monolithic column, is a column used in high-performance liquid chromatography (HPLC) which contains a porous material which forms channels inside the column. In most HPLC configurations, particulate packed columns are used; in these configurations, tiny beads of an inert substance, typically a modified silica, are used inside the column.

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  • A monolithic HPLC column, or monolithic column, is a column used in high-performance liquid chromatography (HPLC) which contains a porous material which forms channels inside the column. In most HPLC configurations, particulate packed columns are used; in these configurations, tiny beads of an inert substance, typically a modified silica, are used inside the column.
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