State Route 104 (SR 104) is a north–south highway in Southern Ohio. Its southern terminus is at U.S. Route 23 in Portsmouth, Ohio and its northern terminus is at U.S. Route 33 in Columbus. The route passes through or close to the towns of Portsmouth, West Portsmouth, Coles Park, Waverly, Chillicothe, Grove City, and Columbus. From Waverly to Chillicothe, it overlaps U.S.
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