State Route 278 (SR 278) is a north–south state highway located in the southeastern part of the U.S. state of Ohio. The southern terminus of SR 278 is at US 50 approximately 4.75 miles (7.64 km) east of McArthur. The highway's northern terminus is at the T-intersection it has with SR 595 nearly 5.50 miles (8.85 km) northwest of Nelsonville. Established in the early 1930s, SR 278 primarily connects rural communities in Vinton, Hocking, and Athens Counties.
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