Portrait of Simonetta Vespucci as Cleopatra is a tempera painting on canvas (57x42 cm) by the Italian Renaissance painter Piero di Cosimo, dating from about 1480 or 1490. It is in the Musée Condé in Chantilly, France.Simonetta Vespucci was a Genoese noblewoman who married Marco Vespucci of Florence at the age of either 15 or 16, and who was renowned for being the greatest beauty of her age - certainly of the city of Florence.
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