Route 161 is a north/south highway south of the St. Lawrence River in Quebec, Canada. Its current northern terminus is east of the junction of Autoroute 55 in Saint-Wenceslas, and its southern terminus is at the border of Maine in the USA, where it continues as Maine State Route 27.On July 6, 2013, the route was severed at Lac-Mégantic, Quebec by an oil train derailment. Ministry of Transport consultants began surveying a site for a new bridge across the Chaudière River in August 2013.
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