Sepia appellofi is a species of cuttlefish native to the northwestern Pacific Ocean, specifically the Tsushima Strait and waters between Kyūshū and southern Honshū, Japan. It lives at a depth of up to 350 m.S. appellofi grows to a mantle length of 90 mm.The type specimen was collected near Misaki, Japan and is deposited at the Zoologische Staatssammlung Muenchen.
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