U.S. Route 221 is a spur of U.S. Route 21. It runs for 734 miles (1,181 km) from Perry, Florida at U.S. Routes 19/98/27 Alternate to Lynchburg, Virginia at U.S. Route 29 (Lynchburg Expressway). It passes through the states of Florida, Georgia, South Carolina, North Carolina, and Virginia.
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