U.S. Route 278 is a parallel route of U.S. Route 78. It currently runs for 1,074 miles (1,728 km) from Hilton Head Island, South Carolina to Wickes, Arkansas at U.S. Route 71/U.S. Route 59. It is longer than its parent highway, US 78. US 278 passes through the states of South Carolina, Georgia, Alabama, Mississippi, and Arkansas.
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