"What a Difference a Day Makes" is the twenty-second episode of the fifth season of the American television medical drama, Grey's Anatomy and the show's 100th episode overall. Written by series creator Shonda Rhimes and directed by Rob Corn, the episode was originally broadcast on the American Broadcasting Company (ABC) in the United States on May 7, 2009. Grey's Anatomy centers around a group of young doctors in training. In this episode, a wedding takes place.
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