The 15th Syracuse Grand Prix was a motor race, run to Formula One rules, held on 1 May 1966 at Syracuse Circuit, Sicily. The race was run over 56 laps of the circuit, and was won by British driver John Surtees in a Ferrari 312.Jack Brabham, Vic Wilson and Denny Hulme all failed to post a time during practice, and lined up on the grid behind the last driver to post a time, André Wicky, whose time was 37.4 seconds slower than Surtees's pole time.