Achamma Mathai was an Indian social worker, women's rights activist, a co-founder of Dr. John Mathai Centre, an institute of Information Technology, Economics, Management, Theatre Arts and Music under the University of Calicut and the wife of John Mathai, the first Railway Minister of India and a former Finance minister. During her stay in Delhi, when her husband was serving in the Union Ministry, she was reported to have been involved in activities related to children's education.