State Route 10 (SR-10) is a west–east state highway in the southern part of the U.S. state of Alabama. It is the lowest even-numbered route in the state that is not an unsigned partner route assigned to a U.S. Highway. It is also the only signed state route that extends from the Mississippi state line to the Georgia state line. The western terminus of the route is in northwestern Choctaw County near the community of Yantley, where it serves as a continuation of Mississippi Highway 19.