State Route 133 or SR-133 is a mostly multi-lane highway and is a primary artery through Muscle Shoals and Florence in northwest Alabama. The route begins at SR-20 (Alternate US-72) just south of Muscle Shoals. It runs north along Wilson Dam Road, becoming a six-lane highway at Avalon Avenue. It crosses the Tennessee River and enters Florence on the new Patton Island Bridge. From there, it narrows to four lanes and runs east along Veterans Drive to Cox Creek Parkway.