State Route 157 (SR-157) is a 76-mile-long (122 km) route in the northern and northwestern parts of the U.S. state of Alabama. The southern terminus of the route is at the junction with U.S. Route 278 (US-278) approximately 10 miles (16 km) east of Cullman, and the northern terminus of the route is at the Tennessee state line northwest of Florence. SR-157 continues as Tennessee State Route 227 once it crosses into Tennessee.