Andrew J. Applegate (October 14, 1833 – August 21, 1870) was the first Lieutenant Governor of Alabama, serving during Reconstruction. A Republican, Applegate served Governor William H. Smith of the same political party, from 1868-1870.A son of Benjamin and Rebecca Applegate, he grew up on a farm near Georgetown, Ohio. His father's family had immigrated from Holland, settling in Pennsylvania and then Kentucky, until finally moing to Ohio.