Applegate Lake is a 988-acre (400 ha) reservoir located in the Rogue River – Siskiyou National Forest about 27 miles (43 km) southwest of Medford in the U.S. state of Oregon. It is 16 miles (26 km) south of Oregon Route 238 along Applegate River Road and slightly north of the Oregon–California border. The lake is an impoundment of the Applegate River about 46 miles (74 km) from its confluence with the Rogue River.