Appomattox County is a United States county located in the Piedmont region and near the center of the Commonwealth of Virginia. The county is part of the Lynchburg, VA Metropolitan Statistical Area, and its county seat is the town of Appomattox.Appomattox County was created in 1845 from sections of four other Virginia counties. The name of the county comes from the Appomattox River, which rises in the county, while the river was named for the Appamatuck Indians.