Barbara Ann Wilberforce (née Spooner) (24 December 1777, Birches Green, Erdington, Warwickshire – 21 April 1847, The Vicarage, East Farleigh, Kent) was the spouse of abolitionist and MP William Wilberforce. She was the eldest daughter and third child of Isaac Spooner of Elmdon Hall, Warwickshire, a banker of Birmingham, and his wife, Barbara Gough-Calthorpe, the sister of the first Lord Calthorpe.