The Battle of Issus occurred in southern Anatolia, in November 333 BC between the Hellenic League led by Alexander the Great and the Achaemenid Persia, led by Darius III, in the second great battle of Alexander's conquest of Asia. The invading Macedonian troops defeated Persia. After the Hellenic League soundly defeated the Persian satraps of Asia Minor (led by the Greek mercenary, Memnon of Rhodes) at the Battle of the Granicus, Darius took personal command of his army.