Big Bone is an unincorporated community in southern Boone County, Kentucky, United States. It is bounded on the west by the Ohio River, and Rabbit Hash, on the south by Big Bone Creek, which empties into the river at Big Bone Landing. The northern extent is along Hathaway Road, and the eastern portion extends not further than U.S. 42, and is approached from that direction by Beaver Road (Route 338) coming from either Richwood or Walton.