Birch Island Run is a stream in Cameron County and Clinton County, Pennsylvania in the United States. It is a tributary of the West Branch Susquehanna River and is 7.2 miles (11.6 km) long. There are a number of coal seams in the Birch Island Run watershed, as well as iron ore. Mining has been done in the watershed. The watershed is 15.3 square miles in area and is almost entirely forested. The stream's tributaries include Little Birch Island Run and Amos Branch.