For information on the regent of the Netherlands, see Charles of Lorraine.Charles of Lorraine, Duke of Mayenne (26 March 1554 – 3 October 1611), or Charles de Guise, was a French nobleman of the house of Guise and a military leader of the Catholic League, which he headed during the French Wars of Religion, following the assassination of his brothers at Blois in 1588. In 1596, when he made peace with Henri of Navarre, the wars were essentially at an end.