Chickasha /ˈtʃɪkəʃeɪ/ is a city in and the county seat of Grady County, Oklahoma, United States. The population was 16,036 at the 2010 census. Chickasha is home to the University of Science and Arts of Oklahoma. The city is named for, and strongly connected to Native American heritage as Chickasha (Chikashsha) is the Choctaw word for Chickasaw.