Chuan He (simplified Chinese: 何川) (born February 25, 1972) is a Chinese-American chemical biologist, and is currently the John T. Wilson Distinguished Service Professor and Director of the Institute for Biophysical Dynamics at The University of Chicago, and an Investigator of the Howard Hughes Medical Institute. Chuan He is best known for his work in discovering and deciphering reversible RNA methylation in post-transcriptional gene expression regulation.