Clare is a city in Clare and Isabella counties in the U.S. state of Michigan. Located primarily in Clare County, the population was 3,118 at the 2010 census. North-south U.S. Highway 127 (US 127) forms the eastern boundary for much of the city and has a junction with east-west US 10 on the east side of the city. US 10 connects with Midland, 33 miles (53 km) to the southeast, and with US 131 at Reed City, 44 miles (71 km) to the west.