Clarice Orsini (c. 1453 – 30 July 1488) was the daughter of Jacopo (Giacomo) Orsini, Lord of Monterotondo and Bracciano, and his wife and cousin Maddalena Orsini. Born in the Papal States, she is most known as the wife of Lorenzo de' Medici (Lorenzo the Magnificent), de facto ruler of the Florentine Republic. She was the mother of Pope Leo X.Lorenzo and Clarice were married by proxy on 7 February 1469.