Colombophis ("snake of Colombia" in Greek) is an extinct genus of snakes of the clade Alethinophidia, a group of "primitive" snakes. The genus was first recognized in the formation Villavieja in the town of Los Mangos, part of the known fossil fauna of La Venta in the department of Huila (Colombia), in the middle Miocene. With the remains of a fossil snake was erected the species Colombophis portai in 1977, based on forty fragmentary vertebrae.