DR-5 is of one of the main highways in the Dominican Republic. The highway begins at a T-interchange with DR-1 in Villa Bisonó in the small town of Navarrete located about 20 kilometers northwest of Santiago de los Caballeros. Initially DR-5 starts north of Santiago with a junction with DR-1. DR-1 continues northwest to Monte Cristi while DR-5 turns southeast to the Cities of Puerto Plata, Sosua, and its ending point at the Samana Province.