The Daniel Boone Home is a historic site in Defiance, Missouri, United States. The house was built by Daniel Boone's youngest son Nathan Boone, who lived there with his family until they moved further south in 1837. The Boones had moved there from Kentucky in late 1799. Nathan later said, "In the summer of 1800, I erected a good substantial log house, and several years after that I replaced it with a commodious stone building.