The David L. Shirk Ranch is a historic ranch located in the Guano Valley of eastern Lake County, Oregon, United States. The ranch was originally homesteaded in 1881. It was purchased by David L. Shirk in 1883. He operated the ranch until 1914. The property was acquired by the United States Government in 1942. The ranch is now administered by the Bureau of Land Management. The remaining historic ranch buildings are listed on the National Register of Historic Places.