Delaware Route 48 (DE 48) is a state highway in New Castle County, Delaware. The route runs from DE 41 in Hockessin east to U.S. Route 13 Business (US 13 Bus.) in downtown Wilmington. The route passes through suburban areas of Wilmington such as Lancaster Pike, intersecting DE 100 and DE 141. DE 48 continues into Wilmington as Lancaster Avenue and intersects DE 2, where it splits into the one-way pair of Lancaster Avenue eastbound and Second Street westbound.