Derek DeSantis is a musician for various rock/metal bands in America. He was first the bassist of the band Twisted Method, which disbanded after the band's guitarist and founder, Andrew Howard, died. Later on, DeSantis and the vocalist to Twisted Method, Tripp Tribbett, met with the vocalist and lead guitarist to the band Dope, Edsel Dope (vocalist) and Virus (guitarist), and created the band MakeShift Romeo.