Desperately Seeking Susan is a 1985 American comedy-drama film directed by Susan Seidelman and starring Rosanna Arquette and Madonna.Set in New York, the plot involves the interaction between two women: a bored housewife and a bohemian drifter, linked by various announcements in the personal column of a newspaper. It reflected Manhattan’s New Wave scene of the early 80’s, in which Madonna had come to prominence as a singer.