Ecsenius shirleyae, known commonly as the Shirley's blenny in Indonesia, is a species of combtooth blenny in the genus Ecsenius. It is found in the western Pacific ocean, specifically in Indonesia. It can reach a maximum length of 2.8 centimetres. The species was named in honour of Springer's wife, Shirley. It is considered most similar to its sister species E. bimaculatus.