Frank A. DeSimone (July 17, 1909 – August 4, 1967) was the Boss of the Los Angeles crime family from 1956 to 1967. DeSimone was the son of former don Rosario DeSimone. He was sometime referred to as "One Eye" because one of his eyes drooped, in the same way as Charles "Lucky" Luciano. Frank DeSimone's well-known nephew, Thomas DeSimone, was an enforcer for the Lucchese crime family. He was also related to Simone Scozzari and Joseph Civello.