Gash-Setit is a 709 km2 (274 sq mi) designated national wildlife reserve and historical area of western Eritrea. It is located in much of Omhajer District and Haykota District south west of Haykota between the market town of Tesseney in the Gash-Barka region. The name is derived from the two rivers, the Gash and the Setit (Tekezé) River.